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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

221
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
221
Panic Disorder01:27

Panic Disorder

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Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
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Updated: Nov 9, 2025

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Posttraumatic Stress Disorder Brain Transcriptomics: Convergent Genomic Signatures Across Biological Sex.

Jiawei Wang1, Hongyu Zhao1, Matthew J Girgenti2

  • 1Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.

Biological Psychiatry
|April 12, 2021
PubMed
Summary
This summary is machine-generated.

Posttraumatic stress disorder (PTSD) molecular pathology is sex-specific. Genomic studies reveal differences in PTSD heritability and gene regulation between sexes, impacting brain function, particularly GABAergic signaling and immune responses.

Keywords:
GenomicsPTSDPostmortem brainPrefrontal cortexStressTranscriptomics

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Area of Science:

  • Neuroscience
  • Genomics
  • Psychiatry

Background:

  • Posttraumatic stress disorder (PTSD) affects women disproportionately.
  • Neurobiological evidence indicates sex-specific structural brain differences in PTSD.
  • The molecular pathology of PTSD is not fully understood.

Purpose of the Study:

  • To review the current state of PTSD genomics, focusing on sex differences.
  • To explore sex-specific molecular determinants of PTSD.
  • To examine the impact of sex on PTSD heritability and gene regulation.

Main Methods:

  • Review of current genomic technologies and PTSD research.
  • Analysis of sex-specific differences in gene regulation.
  • Examination of dysregulated genomic regulation in specific cell types in PTSD.

Main Results:

  • PTSD molecular effects are predominantly sex-specific.
  • GABAergic (gamma-aminobutyric acidergic) signaling and immune function are key areas of sex-specific molecular dysregulation.
  • Sex influences PTSD heritability and gene expression in the brain.

Conclusions:

  • Genomic approaches are crucial for understanding sex-specific PTSD mechanisms.
  • Sex-specific gene regulation plays a significant role in PTSD pathophysiology.
  • Further research into cell-type-specific genomic dysregulation is warranted.