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Updated: Aug 14, 2026
Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
Experience-dependent modifications of kitten striate cortex are not prevented by thalamic lesions that include the
M F Bear1, A Kleinschmidt, W Singer
1Max-Planck-Institut für Hirnforschung, Frankfurt, Federal Republic of Germany.
Abstract:
It has been shown previously that surgical lesions of the antero-medial thalamus interfere with ocular dominance modifications that normally result from monocular deprivation in young kittens (Singer 1982). The aim of the present study was to determine whether this effect was due specifically to the destruction of the visual cortical projections of the anterior intralaminar nuclei. We report here that large excitotoxin lesions of the anterior dorsal thalamus have no effect on the cortical response to monocular deprivation. These data indicate that the intralaminar projection is not essential for ocular dominance plasticity.
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