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Related Experiment Video

Updated: Nov 9, 2025

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
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Probiotics in food allergy.

Maurizio Mennini1, Stefania Arasi, Maria Cristina Artesani

  • 1Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Current Opinion in Allergy and Clinical Immunology
|April 12, 2021
PubMed
Summary

Current evidence does not support probiotics for food allergy (FA) treatment or prevention. Further research is needed to identify specific strains and optimal protocols for potential immunomodulation.

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Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Gut microbiome alterations are implicated in food allergy (FA) pathogenesis.
  • Probiotics are investigated as potential modulators of the gut immune system.

Purpose of the Study:

  • To review the existing literature on the role of probiotics in managing food allergy.
  • To assess the current evidence for probiotic efficacy in FA prevention and treatment.

Main Methods:

  • Nonsystematic literature review.
  • Analysis of animal models, in vitro studies, and human clinical data.

Main Results:

  • Animal and in vitro studies suggest a protective role for probiotics in FA.
  • Inconsistent evidence exists regarding specific probiotic species, dosages, and treatment durations for effective immunomodulation.
  • Novel approaches involving machine learning to identify 'missing' microbes for early life supplementation are proposed for atopic disease prevention.

Conclusions:

  • No consistent evidence supports the use of probiotics for FA treatment or prevention.
  • Major scientific societies do not currently recommend probiotics for FA.
  • Further research is essential to explore targeted probiotic interventions and novel microbial strategies.