Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic studies of tyrosine phosphatase SHP2 in hypoxic environment to promote angiogenesis in HCC by modulating the ROS/Src pathway.

Scientific reports·2026
Same author

Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis.

Brain and behavior·2026
Same author

Dual-functional nanoengineering <i>via</i> molecular pillaring and conductive hybridization for high-performance aqueous zinc-ion batteries.

Chemical science·2026
Same author

Unraveling the causal link between inflammatory cytokines and hypertensive renal disease: a Mendelian randomization analysis.

International urology and nephrology·2025
Same author

Nucleus-targeted protein delivery <i>via</i> lysine dendron conjugation.

Chemical communications (Cambridge, England)·2025
Same author

Design Strategies, Challenges, and Prospects of Nanomaterials for Aqueous Zn-Iodine Batteries.

ACS nano·2025

Related Experiment Video

Updated: Nov 9, 2025

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
10:33

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

1.5K

Ginseng polysaccharides: A potential neuroprotective agent.

Na Wang1, Xianlei Wang2, Mengjiao He1

  • 1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People's Republic of China.

Journal of Ginseng Research
|April 12, 2021
PubMed
Summary

Ginseng polysaccharides (GP) show promise in treating nervous system diseases (NSDs) by regulating immune responses, inflammation, and oxidative stress. Further research into GP

Keywords:
AG, ArabinogalactanBBB, Blood–brain barrierBDNF, Brain-derived neurotrophic factorGP, Ginseng polysaccharidesGinsengHG, HomogalacturonanIFN-γ, Interferon-γIL-17α, Interleukin-17 αMS, Multiple sclerosisMolecular mechanismNSDs, Nervous system diseasesNervous systemPolysaccharidesRG, RhamnogalacturonanTNF-α, tumor necrosis factor-α

More Related Videos

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.7K
Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
08:53

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Published on: December 9, 2018

7.6K

Related Experiment Videos

Last Updated: Nov 9, 2025

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
10:33

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

1.5K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.7K
Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
08:53

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Published on: December 9, 2018

7.6K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Immunology

Background:

  • Nervous system diseases (NSDs) present complex treatment challenges, particularly with an aging global population.
  • Ginseng polysaccharides (GP), derived from ginseng, exhibit significant immune-regulatory, antioxidant, and anti-inflammatory properties.
  • The potential therapeutic applications of GP in neurological disorders are gaining research interest due to their known biological activities.

Purpose of the Study:

  • To review and synthesize existing research on the effects and mechanisms of ginseng polysaccharides (GP) in treating nervous system diseases (NSDs).
  • To explore the neuroprotective potential of GP by examining their impact on immune regulation, inflammation, oxidative damage, and signaling pathways.
  • To discuss the structure-activity relationships of GP and provide insights for their future development as neuroprotective agents.

Main Methods:

  • Comprehensive literature review of studies investigating ginseng polysaccharides (GP) and their effects on nervous system diseases (NSDs).
  • Analysis of experimental data focusing on the mechanisms by which GP modulate immune responses, inflammation, oxidative stress, and relevant signaling pathways.
  • Summarization of structure-activity relationships to understand the key components of GP responsible for neuroprotection.

Main Results:

  • Ginseng polysaccharides (GP) demonstrate a significant ameliorative effect on nervous system diseases (NSDs).
  • GP exert neuroprotective effects through the regulation of the immune system, inflammatory responses, and oxidative damage.
  • GP influence key signaling pathways implicated in the pathogenesis of neurological disorders, contributing to their therapeutic potential.

Conclusions:

  • Ginseng polysaccharides (GP) represent a promising therapeutic agent for nervous system diseases (NSDs).
  • The multifaceted mechanisms of GP, including immune modulation and antioxidant effects, underscore their neuroprotective capabilities.
  • Further research and development of GP are warranted for their clinical utilization in treating neurological conditions.