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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Related Experiment Video

Updated: Nov 9, 2025

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes
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Non-coding RNAs in Cardiac Regeneration.

Ting Yuan1, Jaya Krishnan1

  • 1Institute of Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany.

Frontiers in Physiology
|April 12, 2021
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are key regulators of cardiac regeneration. Modulating ncRNAs offers promising new strategies for treating heart failure by promoting heart tissue repair.

Keywords:
cardiac differentiationcardiac regenerationcardiac reprogrammingcardiomyocyte apoptosiscardiomyocyte proliferationlncRNAmiRNAncRNA

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Regenerative Medicine

Background:

  • The adult heart has limited capacity for self-repair after injury, leading to heart failure.
  • Current treatments for severe heart damage are insufficient, highlighting the need for regenerative therapies.
  • Cardiomyocyte proliferation, differentiation, and survival are critical targets for cardiac regeneration.

Purpose of the Study:

  • To review the role of non-coding RNAs (ncRNAs) in cardiac regeneration.
  • To explore how ncRNAs regulate cardiomyocyte signaling in cardiac repair.
  • To highlight therapeutic strategies targeting ncRNAs for heart failure treatment.

Main Methods:

  • Comprehensive literature review of studies on ncRNAs and cardiac regeneration.
  • Analysis of ncRNA involvement in cardiomyocyte physiology and pathology.
  • Examination of *in vitro* and *in vivo* models of cardiac regeneration.

Main Results:

  • Non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are crucial regulators of cardiac regeneration.
  • ncRNAs modulate key signaling pathways governing cardiomyocyte proliferation, differentiation, and survival.
  • Evidence supports the role of ncRNAs in both promoting and inhibiting cardiac repair processes.

Conclusions:

  • ncRNAs represent a significant class of molecules involved in cardiac regeneration.
  • Targeting ncRNA function offers novel therapeutic avenues for treating heart failure.
  • Further research into ncRNA-driven mechanisms can lead to advanced regenerative strategies for the heart.