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Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts
Jaya Mehta1, Juliana M Kling2, JoAnn E Manson3
1Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, United States.
Frontiers in Endocrinology
|April 12, 2021
Summary
Menopausal hormone therapy (HT) is safe for healthy women under 60, offering benefits for symptom relief and osteoporosis prevention. Updated guidelines reflect evolving understanding of HT risks and benefits.
Area of Science:
- Reproductive Endocrinology
- Women's Health
- Clinical Pharmacology
Background:
- Menopausal hormone therapy (HT) prescribing has evolved due to updated risk-benefit analyses.
- The Women's Health Initiative (WHI) trial significantly impacted HT guidelines since 2002.
Purpose of the Study:
- To provide a comprehensive overview of current menopausal hormone therapy (HT).
- To guide clinical decision-making regarding HT use, benefits, and risks.
Main Methods:
- Review of post-intervention analysis and 18-year follow-up data from the WHI trial.
- Analysis of current HT types, routes, and formulations.
- Evaluation of HT benefits and risks across various health outcomes.
Main Results:
- HT risks are low for healthy women <60 or within 10 years of menopause.
- HT benefits, including symptom management and osteoporosis prevention, often outweigh risks.
- Efficacy of HT for vasomotor symptoms and bone health is confirmed.
Conclusions:
- Current evidence supports the safety and efficacy of HT for specific patient populations.
- HT remains a valuable tool for managing menopausal symptoms and preventing osteoporosis.
- Informed clinical decisions require understanding HT's nuanced risk-benefit profile.
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