Neutrophils in COVID-19.

Area of Science:

• Immunology
• Pathophysiology
• Cell Biology

Background:

• Neutrophils are increasingly recognized for their significant role in COVID-19 pathophysiology, especially in severe cases.
• Previously viewed as a uniform cell population, neutrophils exhibit remarkable transcriptional and functional diversity.
• Understanding neutrophil heterogeneity is key to comprehending their involvement in various inflammatory conditions.

Purpose of the Study:

• To highlight immune deviations of neutrophils observed in COVID-19.
• To summarize potential therapeutic strategies targeting neutrophil activity in COVID-19 patients.

Main Methods:

• Review of existing evidence on neutrophil function in COVID-19.
• Analysis of studies detailing neutrophil diversity and immune responses.

Main Results:

• Evidence confirms neutrophils' critical role in severe COVID-19.
• Neutrophil heterogeneity and developmental trajectories are now recognized.
• Immune deviation patterns in COVID-19 neutrophils have been identified.

Conclusions:

• Neutrophil diversity offers insights into their role in COVID-19 and other inflammatory diseases.
• Targeting neutrophil reactivity presents promising therapeutic avenues for COVID-19 management.