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Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
Helen L Stark1, Hayson C Wang1,2, Jasmina Kuburic1
1Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Frontiers in Immunology
|April 12, 2021
Summary
Immune regulatory cellular therapies show promise for transplant patients. Advanced immune monitoring is crucial to understand their in vivo effects and optimize future treatments.
Area of Science:
- Immunology
- Cellular Therapy
- Transplantation
Background:
- Regulatory T cells and mesenchymal stromal cells are emerging cellular therapies for transplant alloresponses.
- Clinical studies confirm the feasibility and safety of these cellular therapeutics.
- Understanding their in vivo impact necessitates advanced immune monitoring.
Purpose of the Study:
- To review current immune monitoring strategies for cellular therapeutics.
- To discuss future immune monitoring methods for transplant alloresponses.
Main Methods:
- Review of existing literature on immune monitoring in cellular therapy.
- Analysis of complementary methods for assessing cellular and molecular phenotypes.
- Evaluation of functional assays for immune cells.
Main Results:
- Current immune monitoring strategies are essential but require advancement.
- A combination of methods is needed for comprehensive immune response assessment.
- Future strategies will likely involve integrated multi-omics and functional analyses.
Conclusions:
- Advanced immune monitoring is critical for the successful clinical application of cellular therapeutics.
- Future research should focus on developing and validating novel monitoring tools.
- Optimized monitoring will enhance the efficacy and safety of transplant treatments.
