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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Related Experiment Video

Updated: Nov 9, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Exosomes in osteosarcoma research and preclinical practice.

Xiao-Bo Zhang^1,2, Rui-Hao Zhang^1,2, Xin Su³

¹Department of Orthopedics, Lanzhou University Second Hospital Lanzhou 730000, Gansu, China.

American Journal of Translational Research

|April 12, 2021

Summary

Exosomes, tiny vesicles involved in cell communication, show promise for treating osteosarcoma (OS). Research highlights their potential in OS diagnosis and therapy, offering new hope for patients with poor prognoses.

Keywords:

Osteosarcoma (OS)challenges exosomes microRNA (miRNA)

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Last Updated: Nov 9, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Published on: April 12, 2019

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Area of Science:

Oncology
Cell Biology
Biochemistry

Background:

Osteosarcoma (OS) is a rare bone cancer with high mortality, especially in metastatic or relapsed cases.
Current treatments like chemotherapy and surgery have limited success for advanced OS.
Exosomes, extracellular vesicles mediating cell communication, are emerging as key players in OS progression.

Purpose of the Study:

To review the multifaceted roles of exosomes in osteosarcoma (OS).
To explore exosome-based strategies for OS diagnosis and targeted therapy.
To identify challenges and future directions for clinical application of exosomes in OS.

Main Methods:

Literature review of studies on exosomes in osteosarcoma.
Analysis of exosome cargo (e.g., microRNAs) for disease detection.
Evaluation of exosome-mediated cell-to-cell communication in OS pathogenesis.

Main Results:

Exosomes influence OS cell function, invasion, metastasis, and drug resistance.
Exosomes can serve as diagnostic markers and therapeutic targets for OS.
Exosome cargo reflects disease progression and treatment response.

Conclusions:

Exosomes offer a promising avenue for targeted osteosarcoma (OS) therapy and diagnosis.
Further research is needed to overcome challenges for clinical exosome application in OS.
Exosomes represent a significant advancement in understanding and treating OS.