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Risk factors for cognitive impairment in patients with first-time ischemic stroke
Guotao Yang1, Conghui Li1, Wenhui Wang1
1Department of The Third Neurology, Cangzhou Central Hospital Cangzhou 061000, Hebei, China.
Insights
Cognitive impairment (CI) affects over half of first-time ischemic stroke patients. Key risk factors include advanced age, diabetes, high CRP and Hcy levels, and stroke severity.
Area of Science:
- Neurology
- Stroke Medicine
- Cognitive Science
Background:
- Cognitive impairment (CI) is a common complication following ischemic stroke.
- Identifying risk factors for CI is crucial for timely intervention and improved patient outcomes.
Purpose of the Study:
- To investigate the independent risk factors associated with cognitive impairment in patients experiencing their first ischemic stroke.
Main Methods:
- Retrospective analysis of clinical data from 180 first-time ischemic stroke patients.
- Patients were categorized into cognitive impairment (MMSE score ≤24) and normal groups.
- Multivariate logistic regression analysis was employed to identify risk factors.
Main Results:
- Cognitive impairment (CI) was observed in 53% of patients.
- Large-artery atherosclerosis subtype and frontal lobe infarction showed higher CI incidence.
- Independent risk factors identified: age ≥60, diabetes, elevated CRP (>6.53 mg/L), elevated Hcy (>13.84 μmol/L), high NIHSS score (>4.37), and low VD (<45.16 nmol/L).
Conclusions:
- First-time ischemic stroke patients exhibit a high incidence of cognitive impairment.
- Age, diabetes, specific inflammatory markers (CRP, Hcy), stroke severity (NIHSS), and vascular factors (VD) are significant predictors of CI.
Objective:
To determine the risk factors for cognitive impairment (CI) in patients with first-time ischemic stroke.
Methods:
The clinical data of 180 patients with ischemic stroke who were admitted to our hospital from January 2018 to December 2019 was retrospectively analyzed. Patients with MMSE score ≤24 were included into the CI group and the rest of the patients were placed into the normal group. Multivariate logistic regression was applied to describe risk factors for CI in patients with first-time ischemic stroke.
Results:
Among the patients with first-time ischemic stroke, 96 cases (53%) developed CI, 84 cases (47%) were normal. In different subtypes of TOAST classifications, patients with large-artery atherosclerosis had the highest CI incidence (66.96%). For different infarction sites, the highest CI incidence occurred in the frontal lobe (82.35%), and the lowest was from cerebellar infarction (37.50%). The difference of CI incidences in the frontal lobe, parietal lobe, temporal lobe and occipital lobe was significant between the two groups (P<0.05). Logistic regression analysis indicated that independent risk factors for CI in patients with first ischemic stroke include age ≥60 years old, diabetes history, CRP >6.53 mg/L, Hcy >13.84 μmol/L, NIHSS score >4.37, VD <45.16 nmol/L, and the difference was statistically significant (P<0.05).
Conclusion:
The study showed a high CI incidence in patients with preexisting ischemic stroke. Age ≥60 years old, history of diabetes mellitus, CRP >6.53 mg/L, Hcy >13.84 μmol/L, NIHSS score >4.37 score, VD <45.16 nmol/L are independent risk factors for CI in patients with first-time ischemic stroke.
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