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Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
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Ethics of primate use.

M J Prescott1

  • 1National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), 20 Park Crescent, London, W1B 1AL, UK.

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|April 12, 2021
PubMed
Summary
This summary is machine-generated.

This article discusses ethical considerations for using non-human primates (NHPs) in research that may cause harm. It guides addressing ethical issues through scientific rationale, the 3Rs principle, and harm-benefit assessments.

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Area of Science:

  • Bioethics
  • Animal Research Ethics

Background:

  • Research involving non-human primates (NHPs) can cause pain, suffering, distress, or lasting harm.
  • Ethical considerations are paramount in scientific procedures utilizing NHPs.

Purpose of the Study:

  • To provide an overview of ethical issues concerning NHP use in research.
  • To offer guidance on addressing these ethical challenges.

Main Methods:

  • Examination of the scientific rationale for NHP utilization.
  • Full implementation of the 3Rs principle (Replacement, Reduction, Refinement) by Russell and Burch (1959).
  • Application of a robust harm-benefit assessment for research proposals involving NHPs.

Main Results:

  • Identified key ethical issues associated with NHP research.
  • Outlined strategies for ethical NHP use in scientific procedures.

Conclusions:

  • Ethical NHP research requires careful scientific justification.
  • Adherence to the 3Rs principle and rigorous harm-benefit analysis are crucial for responsible NHP use.