Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac hyperfunction in insulin-dependent diabetic patients developing microvascular complications.

L Thuesen1, J S Christiansen, C E Mogensen

  • 1University Department of Cardiology, Aarhus Kommunehospital, Denmark.

Diabetes
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Ambulatory pulse pressure, decreased nocturnal blood pressure reduction and progression of nephropathy in type 2 diabetic patients.

Diabetologia·2009
Same author

Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients with left ventricular hypertrophy and diabetes.

Journal of nephrology·2008
Same author

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.

Lancet (London, England)·2007
Same author

Endothelial dysfunction, ambulatory pulse pressure and albuminuria are associated in Type 2 diabetic subjects.

Diabetic medicine : a journal of the British Diabetic Association·2007

Diabetic patients without ischemic heart disease show cardiac hyperfunction, particularly those with early-stage kidney disease (preclinical nephropathy). This cardiac overactivity may stem from increased blood flow in these individuals.

Area of Science:

  • Cardiology
  • Diabetology
  • Nephrology

Background:

  • Insulin-dependent diabetes mellitus is associated with cardiovascular complications.
  • Microvascular disease, such as nephropathy, is a common complication in diabetes.
  • Cardiac function in diabetic patients without ischemic heart disease requires further investigation.

Purpose of the Study:

  • To investigate cardiac function in insulin-dependent diabetic patients without ischemic heart disease.
  • To correlate echocardiographic findings with urinary albumin excretion rate (UAE).
  • To explore the relationship between cardiac hyperfunction and the development of diabetic nephropathy.

Main Methods:

  • Echocardiography was used to assess cardiac function in 80 diabetic patients and 40 healthy controls.

Related Experiment Videos

  • Urinary albumin excretion rate (UAE) was measured to categorize patients based on nephropathy status.
  • Left ventricular fractional shortening (FS), preload, and afterload were analyzed.

    • Main Results:

    • Diabetic patients exhibited increased left ventricular fractional shortening (FS) compared to controls.
    • FS was significantly higher in diabetic patients with preclinical nephropathy (UAE 20-200 µg/min).
    • Patients with preclinical nephropathy showed decreased afterload and unchanged preload, suggesting hyperperfusion.

    Conclusions:

    • A state of cardiac hyperfunction exists in diabetic patients without evident ischemic heart disease.
    • This cardiac hyperfunction is more pronounced in patients developing microvascular disease (preclinical nephropathy).
    • Hyperperfusion may be a contributing factor to cardiac hyperfunction in diabetic patients with preclinical nephropathy.