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Related Experiment Video

Updated: Nov 9, 2025

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Intradialytic hypotension and relationship with cognitive function and brain morphometry.

Santiago Cedeño1, Manuel Desco2, Yasser Aleman2

  • 1Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Clinical Kidney Journal
|April 12, 2021
PubMed
Summary

Intradialytic hypotension (IDH), even when asymptomatic, is linked to reduced brain white matter and hippocampus volume and lower cognitive function in dialysis patients. This highlights the brain's vulnerability to haemodynamic stress during dialysis.

Keywords:
cardiovascular diseasecognitive impairmenthaemodialysisintradialytic hypotensionwhite matter

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Area of Science:

  • Nephrology
  • Neurology
  • Radiology

Background:

  • Dialysis-induced haemodynamic stress may impair central nervous system (CNS) integrity.
  • Investigating the link between intradialytic hypotension (IDH) and brain changes is crucial.

Purpose of the Study:

  • To analyze the relationship between intradialytic hypotension (IDH) and cognitive function.
  • To assess the association between IDH and brain morphometry in chronic kidney disease (CKD) patients undergoing hemodialysis (HD).

Main Methods:

  • The cross-sectional KIDBRAIN study included 68 CKD patients undergoing HD.
  • Analyzed 18 dialysis sessions, recording IDH events.
  • Assessed global cognitive function (GCF) using the Mini-Mental State Examination (MMSE) and brain structure via MRI morphometry (grey matter, white matter, hippocampus).

Main Results:

  • More IDH sessions correlated with lower white matter (WM) and hippocampus volume.
  • Global cognitive function (GCF) was associated with WM volume.
  • Symptomatic IDH was significantly linked to reduced GCF.

Conclusions:

  • Intradialytic hypotension (IDH) is associated with reduced white matter and hippocampus volume and lower GCF in hemodialysis patients, even if asymptomatic.
  • These findings suggest the brain is vulnerable to haemodynamic stress during dialysis sessions.