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Updated: Nov 9, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.7K

Endocrine Therapy-related Endocrinopathies-Biology, Prevalence and Implications for the Management of Breast Cancer

Kristy A Brown1, Eleni Andreopoulou1, Panagiota Andreopoulou1

  • 1Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Oncology & Hematology Review
|April 12, 2021
PubMed

Insights

Endocrine therapy effectively treats estrogen receptor-positive breast cancer but can cause side effects. This review explores the impact of estrogen suppression from multiple scientific perspectives.

Area of Science:

  • Oncology
  • Endocrinology
  • Basic Science

Background:

  • Nearly 270,000 new breast cancer cases in the USA (2019), with over 70% being estrogen receptor-positive.
  • Endocrine therapy, targeting estrogen, is a primary treatment for estrogen receptor-positive breast cancer.
  • Estrogen's vital roles in energy homeostasis and bone health necessitate careful consideration during treatment.

Purpose of the Study:

  • To present a multidisciplinary perspective on the impact of endocrine therapy for breast cancer.
  • To consolidate insights from breast medical oncology, endocrinology, and basic science.

Main Methods:

  • Review of current perspectives on endocrine therapy in breast cancer treatment.
  • Integration of knowledge from clinical and basic science research.

Main Results:

  • Endocrine therapy is effective in approximately 70% of women with estrogen receptor-positive breast cancer.
  • Systemic estrogen inhibition can lead to significant side effects due to estrogen's broader physiological functions.

Conclusions:

  • A comprehensive understanding of endocrine therapy's impact requires integrating clinical and basic science viewpoints.
  • Further research is needed to mitigate side effects while maintaining treatment efficacy.
Keywords:
Endocrine therapybone healthbreast cancerendocrinopathiesmetabolism

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