Related Experiment Video

Updated: Nov 9, 2025

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

13.9K

Aspirin plus ticagrelor or clopidogrel on graft patency one year after coronary bypass grafting: a single-center,

Yangfeng Tang1, Xinli Fan1, Boyao Zhang1

  • 1Department of Cardiothoracic Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, China.

Journal of Thoracic Disease
|April 12, 2021
PubMed

Insights

Aspirin plus ticagrelor and aspirin plus clopidogrel both show high saphenous vein graft patency after coronary artery bypass grafting (CABG). This study found no significant difference in graft patency between the two dual antiplatelet therapy (DAPT) strategies within one year post-CABG.

Area of Science:

  • Cardiology
  • Pharmacology
  • Vascular Surgery

Background:

  • Dual antiplatelet therapy (DAPT) is crucial for early post-operative graft patency after coronary artery bypass grafting (CABG).
  • The optimal DAPT regimen following CABG remains unconfirmed.
  • This study compares aspirin plus ticagrelor versus aspirin plus clopidogrel for saphenous vein graft (SVG) patency.

Purpose of the Study:

  • To evaluate the efficacy of two DAPT strategies on SVG patency within one year post-CABG.
  • To compare aspirin plus ticagrelor against aspirin plus clopidogrel in CABG patients.
  • To investigate the influence of CYP2C19 gene variants on clopidogrel's efficacy.

Main Methods:

  • 147 patients undergoing elective CABG were randomized into two groups: aspirin plus ticagrelor (AT) or aspirin plus clopidogrel (AC).
  • Graft patency was assessed at 12 months using 64-multislice computed tomography angiography (MSCTA).
  • CYP2C19 gene variants were analyzed to determine their impact on clopidogrel efficacy.

Main Results:

  • No significant differences in pre-operative characteristics or intraoperative flow were observed between groups.
  • Major adverse cardiac events (MACEs) and major bleeding rates were similar in both groups.
  • SVG patency rates were high and comparable: 91.0% in the AT group and 89.9% in the AC group (P=0.751).
  • No significant association was found between CYP2C19 genotypes and SVG patency.

Conclusions:

  • Both aspirin plus ticagrelor and aspirin plus clopidogrel achieve high early graft patency after CABG.
  • The choice of DAPT strategy (ticagrelor vs. clopidogrel) does not significantly impact SVG patency within one year.
  • CYP2C19 genotype does not appear to influence SVG patency in patients receiving these DAPT regimens.
Abstract

Keywords:
Antiplatelet therapyclopidogrelcoronary artery bypass grafting (CABG)graft patencyticagrelor

More Related Videos

Microfluidics in Assessing Platelet Function06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.2K
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

15.7K

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
819
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
99
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
107
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
74