Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preliminary Reliability and Validity of SynapTrack, a Smartphone-Based Digital Biomarker Platform for Remote Assessment of Cervical Spondylotic Myelopathy.

medRxiv : the preprint server for health sciences·2026

Same author

Comparative morbidity and outcomes for adult spinal deformity corrections spanning C2-pelvis compared to T4-pelvis: a propensity score-matched analysis.

Spine deformity·2026

Same author

Mechanomyography as a novel marker of nerve dysfunction and recovery in chronic entrapment neuropathy.

Frontiers in neurology·2026

Same author

Validation of Gait Tasks in SynapTrack Mobile App for Cervical Spondylotic Myelopathy.

medRxiv : the preprint server for health sciences·2026

Same author

Surgical Management of Spinal Chondrosarcoma: Retrospective Case Series and Systematic Review of the Literature.

Operative neurosurgery (Hagerstown, Md.)·2026

Same author

Tumor-mimicking primary CNS vasculitis: illustrative case.

Journal of neurosurgery. Case lessons·2026

Same journal

A Retrospective Analysis of Cardiac Anatomy in Patients Undergoing the Fontan Operation.

Cureus·2026

Same journal

A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.

Cureus·2026

Same journal

A Prospective Comparative Study for the Evaluation of Digital Learning as an Academic Tool for MBBS Phase III Students.

Cureus·2026

Same journal

Crossing the Septum: May-Thurner Syndrome and Patent Foramen Ovale as a Dual Mechanism for Recurrent Ischemic Stroke.

Cureus·2026

Same journal

Physical Restraint Practices, Attitudes, and Ethical Perceptions Among Intensive Care Unit (ICU) Doctors and Nurses in Morocco: A Cross-Sectional Survey Highlighting the Training-Use Paradox.

Cureus·2026

Same journal

Reversible Rapidly Progressive Dementia Due to Cerebral Amyloid Angiopathy.

Cureus·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 9, 2025

AC Electrokinetic Phenomena Generated by Microelectrode Structures

AC Electrokinetic Phenomena Generated by Microelectrode Structures

Published on: July 28, 2008

High-Frequency Alternating Current Block Using Macro-Sieve Electrodes: A Pilot Study.

Soumyajit Ray¹, Saad Javeed², Jawad M Khalifeh²

¹Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, USA.

|April 12, 2021

Summary

This summary is machine-generated.

High-frequency alternating current (HFAC) delivered through regenerative macro-sieve electrodes (MSEs) successfully created a reversible nerve conduction block in rats. This approach shows promise for managing conditions involving nerve hyperactivity.

Keywords:

high frequency alternating current macro-sieve electrode nerve conduction block neural prosthetics neuromodulation neuropathic pain peripheral nerve

More Related Videos

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

Related Experiment Videos

Last Updated: Nov 9, 2025

AC Electrokinetic Phenomena Generated by Microelectrode Structures

AC Electrokinetic Phenomena Generated by Microelectrode Structures

Published on: July 28, 2008

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

Area of Science:

Neuroscience
Biomedical Engineering
Regenerative Medicine

Background:

High-frequency alternating current (HFAC) offers a method for rapid, reversible nerve conduction blockade.
Regenerative macro-sieve electrodes (MSEs) are designed to facilitate nerve repair and interface with regenerated nerve tissue.

Purpose of the Study:

To demonstrate the efficacy of HFAC nerve conduction block using regenerative MSEs in a rat sciatic nerve model.
To evaluate dual-electrode MSE configurations for HFAC nerve block delivery.

Main Methods:

Fabrication and implantation of dual-macro-sieve electrode (DMSE) assemblies in transected and repaired rat sciatic nerves.
Testing HFAC stimulation (10-42 kHz, 2-20 V p-p) post-nerve regeneration through MSEs.
Quantification of nerve conduction block via evoked muscle force measurements.

Main Results:

Complete nerve conduction block achieved with DMSEs at 14-26 kHz and 12-20 V p-p.
Threshold voltage for complete block demonstrated a near-linear relationship with frequency.
Partial block thresholds were consistently lower than complete block thresholds for tested frequencies.

Conclusions:

Regenerative MSEs can successfully deliver HFAC for complete and reversible nerve conduction block in regenerated nerve tissue.
This technology provides a proof of concept for potential therapeutic applications in managing neuronal hyperactivity.