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Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia

Asim Haider1, Fareeha Alavi1, Ayesha Siddiqa1

  • 1Internal Medicine, BronxCare Health System, Bronx, USA.

Cureus
|April 12, 2021
PubMed

Insights

This case report details a rare instance of Clostridium paraputrificum bacteremia complicating severe pseudomembranous colitis in an immunocompetent individual. This highlights a potentially underrecognized severe Clostridial infection presentation.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Clostridium species are gram-positive anaerobic bacteria causing diverse human infections.
  • Pseudomembranous colitis (PMC) is a severe infection typically caused by Clostridioides difficile.
  • Clostridial bacteremia often occurs in immunocompromised patients with specific comorbidities.

Observation:

  • A case of fulminant PMC was observed.
  • This severe PMC led to Clostridium paraputrificum bacteremia.

Findings:

  • The patient was otherwise immunocompetent, challenging typical risk profiles for Clostridial bacteremia.
  • This represents the first reported case of C. paraputrificum bacteremia secondary to fulminant PMC.

Implications:

  • This case expands the known spectrum of severe Clostridial infections.
  • It suggests immunocompetent individuals may be susceptible to severe PMC and associated bacteremia.
  • Further research into risk factors and management for such rare presentations is warranted.
Keywords:
clostridium difficle infectionclostridium paraputrificum bacteremiafulminant colitispseudomembranous colitis

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