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Updated: Nov 9, 2025
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview
José Manuel Correia da Costa1,2, Maria João Gouveia1,2,3, Gabriel Rinaldi4
1Centre for the Study in Animal Science (CECA/ICETA), University of Porto, Porto, Portugal.
Frontiers in Cellular and Infection Microbiology
|April 12, 2021
Summary
Helminth infections, particularly chronic ones, can lead to cancer. Understanding these parasitic worm-host interactions is key to developing new treatments targeting both the infection and cancer development.
Area of Science:
- Parasitology
- Oncology
- Immunology
Background:
- Helminthiases are widespread, especially in developing nations.
- Chronic parasitic worm infections are linked to cancer development.
- Mechanisms of helminth-associated carcinogenesis require further investigation.
Purpose of the Study:
- To review current knowledge on chemical carcinogenesis in helminthiases.
- To explore therapeutic strategies for these conditions.
- To identify novel treatment alternatives.
Main Methods:
- Literature review of helminth infections and cancer.
- Analysis of parasite-host interactions.
- Evaluation of chemotherapy and immunotherapy options.
Main Results:
- Chemical carcinogenesis is a hypothesized mechanism in helminth-associated cancers.
- Current knowledge on this link is limited.
- Combined therapeutic approaches targeting parasites and pathologies are recommended.
Conclusions:
- Effective treatment requires addressing both the helminth infection and associated pathologies.
- Host immune response and nutritional status influence treatment success.
- Development of drugs to counteract carcinogenesis is crucial.
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