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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Oncoimmunology Meets Organs-on-Chip

Fabrizio Mattei1, Sara Andreone1, Arianna Mencattini2,3

  • 1Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

Frontiers in Molecular Biosciences
|April 12, 2021
PubMed

Insights

Organs-on-chip (OOC) offer a novel approach to study cancer immunology, overcoming limitations of animal models. These microfluidic systems advance understanding of the tumor microenvironment and immune cell interactions in cancer progression.

Area of Science:

  • Biomedical Research
  • Oncoimmunology
  • Cancer Biology

Background:

  • Oncoimmunology investigates the immune system's role in cancer.
  • Immune cell infiltration and crosstalk within the tumor microenvironment are crucial.
  • Current animal models present ethical and time constraints.

Purpose of the Study:

  • To review the state-of-the-art of microfluidics in oncoimmunology.
  • To highlight the impact of organs-on-chip (OOC) in this field.
  • To underscore the importance of OOC for studying tumor microenvironment complexity.

Main Methods:

  • Review of microfluidic technologies and OOC systems.
  • Analysis of OOC applications in oncoimmunology research.
  • Discussion of OOC's role in modeling cell-cell interactions.

Main Results:

  • Organs-on-chip provide innovative platforms for studying oncoimmunology.
  • OOC enable investigation of immune cell-cancer cell crosstalk.
  • These systems offer an alternative to traditional animal models.

Conclusions:

  • Microfluidic-based OOC are transformative tools in oncoimmunology.
  • OOC advance the understanding of complex tumor microenvironments.
  • OOC pave the way for novel cancer treatment strategies.
Keywords:
Cell on ChipOncoimmuno chipOrgan on Chipcancer immunologyhuman on chipmicrofluidic devicepersonalized medicinetumor microenvironment

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