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Updated: Nov 9, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Oncoimmunology Meets Organs-on-Chip.

Fabrizio Mattei¹, Sara Andreone¹, Arianna Mencattini^2,3

¹Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

Frontiers in Molecular Biosciences

|April 12, 2021

Summary

Organs-on-chip (OOC) offer a novel approach to study cancer immunology, overcoming limitations of animal models. These microfluidic systems advance understanding of the tumor microenvironment and immune cell interactions in cancer progression.

Keywords:

Cell on Chip Oncoimmuno chip Organ on Chip cancer immunology human on chip microfluidic device personalized medicine tumor microenvironment

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Area of Science:

Biomedical Research
Oncoimmunology
Cancer Biology

Background:

Oncoimmunology investigates the immune system's role in cancer.
Immune cell infiltration and crosstalk within the tumor microenvironment are crucial.
Current animal models present ethical and time constraints.

Purpose of the Study:

To review the state-of-the-art of microfluidics in oncoimmunology.
To highlight the impact of organs-on-chip (OOC) in this field.
To underscore the importance of OOC for studying tumor microenvironment complexity.

Main Methods:

Review of microfluidic technologies and OOC systems.
Analysis of OOC applications in oncoimmunology research.
Discussion of OOC's role in modeling cell-cell interactions.

Main Results:

Organs-on-chip provide innovative platforms for studying oncoimmunology.
OOC enable investigation of immune cell-cancer cell crosstalk.
These systems offer an alternative to traditional animal models.

Conclusions:

Microfluidic-based OOC are transformative tools in oncoimmunology.
OOC advance the understanding of complex tumor microenvironments.
OOC pave the way for novel cancer treatment strategies.