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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
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Chemotherapy in NEN: still has a role?
Paula Espinosa-Olarte1, Anna La Salvia1, Maria C Riesco-Martinez1
1Oncology Department, Hospital Universitario, 12 de Octubre, Imas12, UCM, Madrid, Spain.
Reviews in Endocrine & Metabolic Disorders
|April 12, 2021
Summary
Chemotherapy is crucial for advanced neuroendocrine neoplasms (NENs), especially pancreatic NENs and high-grade tumors. This review examines chemotherapy
Area of Science:
- Oncology
- Endocrinology
- Tumor Biology
Background:
- Neuroendocrine neoplasms (NENs) present diverse clinical and biological behaviors.
- Prognostic factors include primary site, disease extent, differentiation, and receptor expression.
- Treatment strategies are guided by these prognostic factors.
Purpose of the Study:
- To comprehensively review the evidence for chemotherapy in lung and gastroenteropancreatic (GEP) NENs.
- To critically discuss the role of chemotherapy within the NEN treatment algorithm.
Main Methods:
- Systematic review of existing literature on chemotherapy for NENs.
- Critical analysis of clinical trial data and treatment guidelines.
- Discussion of chemotherapy's place in managing advanced NENs.
Main Results:
- Recent advances include somatostatin analogues, 177Lu-oxodotreotide, sunitinib, and everolimus for specific NEN subtypes.
- Chemotherapy remains essential for pancreatic NENs and high-grade/symptomatic NENs.
- Evidence for chemotherapy's efficacy in lung and GEP NENs is reviewed.
Conclusions:
- While novel therapies have expanded options, chemotherapy retains a vital role in NEN management.
- Chemotherapy is particularly important for advanced, high-grade, or symptomatic NENs.
- Further discussion is needed to optimize chemotherapy's integration into NEN treatment algorithms.
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