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Neuromodulation techniques for cancer pain management
David J Magee1,2, John Schutzer-Weissmann2, Erlick A C Pereira3,4
1Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research.
Current Opinion in Supportive and Palliative Care
|April 12, 2021
Summary
Intrathecal drug delivery (ITDD) and neuromodulation offer advanced cancer pain management options. These techniques are underutilized in the UK but show promise for patients with refractory pain or side effects.
Area of Science:
- Pain Management
- Oncology
- Neuromodulation
Background:
- 5-15% of cancer patients require advanced pain management.
- Current UK procedures for cancer pain analgesia and ITDD implantation are notably low.
- Significant unmet clinical need exists for effective cancer pain management.
Purpose of the Study:
- To review emerging evidence for intrathecal drug delivery (ITDD) in cancer pain.
- To provide a narrative review of other neuromodulatory techniques for cancer pain.
- To highlight the underutilization of these advanced techniques in the UK.
Main Methods:
- Literature review of recent studies on ITDD for cancer pain.
- Narrative review of neuromodulatory techniques: spinal cord stimulation, peripheral nerve stimulation, and acupuncture.
- Analysis of current UK practices in advanced cancer pain management.
Main Results:
- Recent studies report positive outcomes for ITDD in cancer pain management.
- The evidence base for neuromodulation in cancer pain is growing but remains sparse compared to non-malignant pain.
- ITDD and neuromodulation are underutilized in the UK.
Conclusions:
- ITDD and neuromodulatory techniques offer potential for improved cancer pain management.
- These advanced methods can benefit cancer patients with refractory pain or severe side effects from systemic analgesics.
- Increased utilization of ITDD and neuromodulation is warranted in the UK.
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