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Renal dysfunction in systemic sclerosis beyond scleroderma renal crisis.

George Iliopoulos1, Dimitrios Daoussis2,3

  • 1Department of Rheumatology, University of Patras Medical School, Patras, Greece.

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Summary
This summary is machine-generated.

Systemic sclerosis (SSc) patients frequently experience kidney problems beyond scleroderma renal crisis (SRC). Regular glomerular filtration rate (GFR) assessment is crucial for monitoring renal function in SSc.

Keywords:
Glomerular filtration rateProteinuriaRenal dysfunctionSclerodermaSystemic sclerosis

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Area of Science:

  • Nephrology
  • Rheumatology
  • Systemic Autoimmune Diseases

Background:

  • Research on renal involvement in Systemic Sclerosis (SSc) predominantly focuses on Scleroderma Renal Crisis (SRC).
  • Limited data exist regarding non-SRC renal impairment in SSc patients.
  • Understanding broader renal dysfunction is critical for comprehensive SSc patient care.

Purpose of the Study:

  • To investigate the prevalence and characteristics of renal dysfunction in Systemic Sclerosis (SSc) beyond Scleroderma Renal Crisis (SRC).
  • To evaluate the suitability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula for assessing renal function in SSc.
  • To emphasize the importance of regular renal function monitoring in SSc patients.

Main Methods:

  • Conducted an electronic literature search using keywords: systemic sclerosis, scleroderma, renal dysfunction, kidney, glomerular filtration rate (GFR), proteinuria, and hematuria.
  • Included studies focusing on renal dysfunction in SSc outside of SRC.
  • Analyzed data from 796 SSc patients across five studies.

Main Results:

  • A significant proportion of SSc patients exhibit impaired kidney function: 31.5% had GFR < 90 ml/min, and 19.5% had GFR < 60 ml/min.
  • The CKD-EPI formula demonstrated comparable results to measured GFR, suggesting its utility for renal function assessment in SSc.
  • Renal dysfunction is a common complication in SSc, extending beyond SRC.

Conclusions:

  • Renal dysfunction is not uncommon in patients with Systemic Sclerosis (SSc).
  • Regular assessment of renal function, particularly using GFR estimation via the CKD-EPI formula, is recommended for all SSc patients.
  • Proactive monitoring can aid in the early detection and management of kidney complications in SSc.