Contribution of Arab Countries to Familial Mediterranean Fever Research: a PubMed-based bibliometric analysis

Diala El Masri1, Bachar Alsaayed2, Jad El Masri3,4

  • 1Faculty of Arts and Sciences, University of Balamand, Nord, Lebanon.

Insights

Research from Arab countries on Familial Mediterranean Fever (FMF) is limited, contributing only 3.80% globally. Tunisia and Lebanon lead in FMF research productivity relative to population and GDP, highlighting a need for increased output.

Area of Science:

  • Autoinflammatory diseases
  • Genetics
  • Epidemiology

Background:

  • Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder.
  • Amyloidosis, a severe complication of FMF, is linked to increased mortality.
  • MEFV gene mutations influence FMF severity and outcomes, including amyloidosis and Bechet's disease.

Purpose of the Study:

  • To numerically assess the Arab world's contribution to Familial Mediterranean Fever (FMF) research.
  • To compare FMF research output from Arab nations with non-Arab countries and analyze normalized productivity.
  • To identify specific research gaps, particularly concerning FMF-related amyloidosis within Arab countries.

Main Methods:

  • PubMed database utilized to quantify FMF-related publications from Arab countries (2004-2019).
  • Article counts normalized by average population and Gross Domestic Product (GDP) for each country.
  • FMF research output compared with select non-Arab countries and analyzed for amyloidosis-specific contributions.

Main Results:

  • The Arab world contributed only 3.80% to global FMF publications, with Turkey alone contributing 24.93%.
  • FMF research constitutes a mere 0.133% of total research from Arab countries.
  • Tunisia and Lebanon demonstrated the highest FMF research productivity when normalized by population and GDP, respectively. Only 8 Arab countries published 13 articles on FMF-related amyloidosis (4.7% of Arab FMF publications).

Conclusions:

  • Significant underrepresentation of Arab countries in global FMF research necessitates increased productivity.
  • Research output disparities highlight the need for targeted initiatives to boost FMF studies in the Arab world.
  • Addressing research limitations is crucial for better understanding and managing FMF and its complications like amyloidosis in affected populations.

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