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The AKT1 proto-oncogene maps to human chromosome 14, band q32
S P Staal1, K Huebner, C M Croce
1Johns Hopkins Oncology Center, John Hopkins University School of Medicine, Baltimore, Maryland 21205.
Genomics
|January 1, 1988
Abstract:
The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.