Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.2K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.2K
Neurulation01:30

Neurulation

43.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
43.7K
Integration of Synaptic Events01:28

Integration of Synaptic Events

2.8K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
2.8K
Neuronal Communication01:28

Neuronal Communication

2.2K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
2.2K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.2K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatially optimized 125I brachytherapy: a novel immunomodulatory approach based on spatially fractionated radiation therapy principles.

Frontiers in oncology·2025
Same author

Does delayed surgery affect survival in recurrent ovarian adult-type granulosa cell tumor? A retrospective study from a high-volume medical center.

Journal of gynecologic oncology·2025
Same author

Multi-omics-guided characterization of neoantigens improves patient stratification and potentiates combinatorial immunotherapy in glioma.

Cell reports·2025
Same author

SMAD signaling in cancer: integrative roles in tumor progression, immune evasion, and therapeutic resistance.

Cytokine·2025
Same author

Mechanisms of glutamate metabolic function and dysfunction in vascular dementia.

Neuroprotection (Chichester, England)·2025
Same author

CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire.

Nature communications·2025
Same journal

Varying susceptibility of subpopulations along the epithelial-mesenchymal spectrum to undergo EMT.

The FEBS journal·2026
Same journal

ALOX15 links lipid metabolism to receptor trafficking in platelet activation.

The FEBS journal·2026
Same journal

A two-component ortholog of the Niemann-Pick C 1 protein is essential for normal growth and sterol trafficking and signaling in Tetrahymena thermophila.

The FEBS journal·2026
Same journal

MMP9 drives cancer invasion by mediating integrin membrane trafficking and stabilization.

The FEBS journal·2026
Same journal

The 2026 Richard Perham Prize winner: Angela M. Gronenborn.

The FEBS journal·2026
Same journal

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding.

The FEBS journal·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

8.1K

Interneuron development and dysfunction.

Jiaxin Yang1, Xiong Yang1, Ke Tang1

  • 1Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, China.

The FEBS Journal
|April 12, 2021
PubMed
Summary
This summary is machine-generated.

Brain interneuron development is crucial for proper brain function. Disruptions in these neurons are linked to neurodevelopmental disorders like autism and schizophrenia.

Keywords:
autism spectrum disorderscerebral cortexintellectual disabilityinterneuronschizophrenia

More Related Videos

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.6K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.2K

Related Experiment Videos

Last Updated: Nov 9, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

8.1K
Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.6K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.2K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The brain's excitation-inhibition balance relies on glutamatergic and GABAergic neurons.
  • Cortical interneurons exhibit remarkable diversity due to their origins, migration, and regulatory factors.
  • Interneuron dysfunction is implicated in neurodevelopmental disorders such as schizophrenia, autism, and intellectual disability.

Purpose of the Study:

  • To review recent findings on cortical interneuron development.
  • To discuss the link between interneuron dysfunction and neurodevelopmental disorders.

Main Methods:

  • Literature review of recent research on interneuron development.
  • Analysis of studies connecting interneuron dysfunction to neurodevelopmental disorders.

Main Results:

  • Cortical interneuron development is complex, involving multiple origins and regulatory mechanisms.
  • Abnormalities in interneuron development and function are strongly associated with neurodevelopmental disorders.

Conclusions:

  • Understanding interneuron development is key to understanding brain function and dysfunction.
  • Further research into interneuron development may offer insights into treating neurodevelopmental disorders.