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Updated: Nov 9, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
Published on: June 8, 2018
Interneuron development and dysfunction
Jiaxin Yang1, Xiong Yang1, Ke Tang1
1Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, China.
Abstract:
Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic factors, extrinsic signals, and activities. Abnormalities of interneuron development lead to dysfunction of interneurons and inhibitory circuits, which are highly associated with neurodevelopmental disorders including schizophrenia, autism spectrum disorders, and intellectual disability. In this review, we mainly discuss recent findings on the development of cortical interneuron and on neurodevelopmental disorders related to interneuron dysfunction.
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