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Molecular Boronic Acid-Based Saccharide Sensors.

George T Williams1, Jonathan L Kedge1, John S Fossey1

  • 1School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, United Kingdom.

ACS Sensors
|April 12, 2021
PubMed
Summary

Boronic acids enable saccharide sensing for biomedical applications. Researchers are developing more selective sensors by understanding fluorescence and binding mechanisms to address challenges posed by saccharide complexity.

Keywords:
biomarkerboronic acidscarbohydratecolorimetricdiabeteselectrochemicalfluorescenceglucosehydrogels

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Carbohydrate Chemistry

Background:

  • Saccharides play crucial roles in biological systems and disease states.
  • Saccharide sensing is vital in medicine, extending beyond glucose monitoring for diabetes.
  • The structural complexity of saccharides poses significant challenges for developing selective sensors.

Purpose of the Study:

  • To explore the relevance of saccharide sensing in biomedical applications.
  • To outline the challenges in developing selective saccharide sensors due to saccharide complexity.
  • To review efforts in understanding fluorescence and binding mechanisms for improved sensor design.

Main Methods:

  • Review of literature on boronic acid-based saccharide sensing.
  • Analysis of fluorescence and binding mechanisms in saccharide-receptor interactions.
  • Examination of strategies for developing selective saccharide receptors.

Main Results:

  • Boronic acids' reversible diol binding is key for saccharide detection.
  • Understanding fluorescence and binding mechanisms is crucial for sensor selectivity.
  • Advances in receptor design have led to improved selectivity for saccharide species.

Conclusions:

  • Saccharide sensing holds significant promise for diverse biomedical applications.
  • Overcoming saccharide complexity is essential for advancing sensor technology.
  • Continued research into binding and fluorescence mechanisms will drive the development of highly selective saccharide sensors.