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Related Experiment Video

Updated: Nov 9, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
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Delivery systems for improving iron uptake in anemia.

Riddhi Trivedi1, Kalyani Barve1

  • 1Shobhaben Pratapbhai Patel- School of Pharmacy and Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra, India.

International Journal of Pharmaceutics
|April 12, 2021
PubMed
Summary

Iron deficiency anemia affects many globally. New strategies like nanotechnology and transdermal systems enhance iron absorption and uptake, overcoming limitations of current oral and intravenous therapies.

Keywords:
EnterocyteFerritinHemoglobinRBCTransporter

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Area of Science:

  • Biochemistry
  • Nanotechnology
  • Hematology

Background:

  • Anemia, often caused by iron deficiency, impacts global health, affecting hemoglobin levels and leading to various conditions.
  • Iron is vital for erythropoiesis, DNA synthesis, immune function, energy production, and cognitive health, necessitating maintained levels.
  • Current iron therapies, including oral and intravenous administration, face challenges in efficacy and patient compliance, particularly in chronic conditions like chronic kidney disease (CKD).

Purpose of the Study:

  • To review innovative strategies for improving iron delivery and absorption.
  • To explore methods for overcoming the disadvantages of existing iron supplementation therapies.
  • To enhance iron uptake and restore iron levels in anemic individuals.

Main Methods:

  • Review of emerging iron delivery systems, including nanotechnology-based approaches and food fortification.
  • Investigation of natural products (polysaccharides, peptides, proteins) and synthetic molecules for iron carrier systems.
  • Exploration of transdermal iron delivery systems like microneedle arrays and iontophoresis.

Main Results:

  • Nanotechnology and food fortification offer novel delivery systems to enhance iron uptake by enterocytes.
  • Natural and synthetic molecules are being utilized to fabricate advanced iron-carrier systems.
  • Transdermal delivery systems and new molecular discoveries present effective alternatives for non-compliant patients.

Conclusions:

  • Innovative strategies are crucial for improving iron therapy outcomes.
  • Nanotechnology and novel biomaterials show promise in enhancing iron absorption and bioavailability.
  • Transdermal delivery offers a viable alternative for patients with challenges in oral iron therapy.