Differentiation of schizophrenics and normal controls is enhanced by the Goodin subtraction procedure

The P300 event-related potential as calculated by the Goodin subtraction procedure (P300g) combines attentive and inattentive condition waveforms in order to isolate components specifically related to target stimulus processing. The waveform was compared with the more commonly employed unsubtracted P300 waveform associated with attended infrequent stimuli (P300ia). The P300g produced the largest overall schizophrenic and control group differences in mean integrated amplitude compared with the P300ia. A group by scalp region interaction in the P300g, indicative of group topographic alterations, was also noted which was not present in the unsubtracted P300ia. Furthermore, the P300g pinpointed the single best scalp region (left temporal) for maximal group separation. This temporal asymmetry was found to originate in the inattentive condition waveforms, indicating a possible abnormality in "nonvoluntary" processing. We conclude that combining attentive and inattentive condition waveforms to form the P300g enhanced clinically relevant group differences between schizophrenics and normals compared with the P300ia.