Centralized Reminder/Recall for Human Papillomavirus Vaccination: Findings From Two States-A Randomized Clinical...

Area of Science:

• Public Health
• Preventive Medicine
• Vaccinology

Background:

• Centralized reminder/recall (C-R/R) systems are effective for childhood immunizations.
• Previous C-R/R using autodialers did not improve human papillomavirus (HPV) vaccine rates.

Purpose of the Study:

• To assess C-R/R for HPV vaccine using various modalities in younger adolescents.
• To evaluate the effectiveness of different reminder/recall methods on HPV vaccination initiation and completion.

Main Methods:

• A three-arm pragmatic randomized controlled trial (RCT) was conducted in primary care practices in Colorado and New York.
• Adolescents aged 11-14 years who had not completed the HPV vaccination series were randomized to receive C-R/R via autodialer, mail, text, or control.

Main Results:

• No significant differences in HPV vaccine series initiation were observed across arms in either state.
• A slight improvement in series completion was noted for the autodialer arm in Colorado (p = .04), and C-R/R reduced time to completion by approximately 2 months.
• No significant differences in initiation or completion were found in New York; costs were low for all intervention modalities.

Conclusions:

• C-R/R demonstrates less benefit for increasing HPV vaccination rates compared to other childhood immunizations.
• Reminder/recall systems may accelerate HPV vaccine series completion with minimal cost, particularly in specific contexts like Colorado.