Catheter ablation in adults with congenital heart disease: A 15-year perspective from a tertiary centre
Victor Waldmann1, Denis Amet2, Alexandre Zhao2
1Adult Congenital Heart Disease Medico-Surgical Unit, Georges Pompidou European Hospital, 75015 Paris, France; Paediatric and Congenital Heart Disease Department, Necker Hospital, 75015 Paris, France.
Insights
Catheter ablation for adult congenital heart disease (ACHD) increased significantly over 15 years. Growing experience and technology improved procedural success and mid-term outcomes in ACHD patients.
Area of Science:
- Cardiology
- Electrophysiology
- Congenital Heart Disease
Background:
- The adult congenital heart disease (ACHD) population is growing, leading to an anticipated rise in catheter ablation procedures.
- Limited data exists on the experience and evolution of catheter ablation in ACHD patients over extended periods.
Purpose of the Study:
- To analyze temporal trends in the volume of catheter ablation procedures performed in ACHD patients.
- To evaluate the outcomes of catheter ablation in ACHD patients over a 15-year period.
Main Methods:
- Retrospective observational study of consecutive ACHD patients undergoing attempted catheter ablation.
- Analysis of acute procedural success and freedom from recurrence at 12 and 24 months.
- Data collected over a 15-year period at a tertiary referral center.
Main Results:
- The annual number of ablations increased from 4 to 60 cases (P<0.001).
- Acute procedural success rose from 45.0% to 93.4% (P<0.001).
- Freedom from recurrence at 12 months improved from 29.4% to 66.2% (P=0.001).
Conclusions:
- Catheter ablation procedures in ACHD patients have markedly increased over 15 years.
- Increased operator experience and technological advancements correlate with improved acute and mid-term outcomes.
- The study highlights a positive trend in managing arrhythmias in the growing ACHD population.
Background:
With the growing adult congenital heart disease (ACHD) population, the number of catheter ablation procedures is expected to dramatically increase. Data reporting experience and evolution of catheter ablation in patients with ACHD, over a significant period of time, remain scarce.
Aim:
We aimed to describe temporal trends in volume and outcomes of catheter ablation in patients with ACHD.
Methods:
This was a retrospective observational study including all consecutive patients with ACHD undergoing attempted catheter ablation in a large tertiary referral centre over a 15-year period. Acute procedural success rate and freedom from recurrence at 12 and 24 months were analysed.
Results:
From November 2004 to November 2019, 302 catheter ablations were performed in 221 patients with ACHD (mean age 43.6±15.0 years; 58.9% male sex). The annual number of catheter ablations increased progressively from four to 60 cases per year (P<0.001). Intra-atrial reentrant tachycardia/focal atrial tachycardia was the most common arrhythmia (n=217, 71.9%). Over the study period, acute procedural success rate increased from 45.0% to 93.4% (P<0.001). Use of irrigated catheters (odds ratio [OR] 4.03, 95% confidence interval [CI] 1.86-8.55), a three-dimensional mapping system (OR 3.70, 95% CI 1.72-7.74), contact force catheters (OR 3.60, 95% CI 1.81-7.38) and high-density mapping (OR 3.69, 95% CI 1.82-8.14) were associated with acute procedural success. The rate of freedom from any recurrence at 12 months increased from 29.4% to 66.2% (P=0.001). Seven (2.3%) non-fatal complications occurred.
Conclusions:
The number of catheter ablation procedures in patients with ACHD has increased considerably over the past 15 years. Growing experience and advances in ablative technologies appear to be associated with a significant improvement in acute and mid-term outcomes.
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