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Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT.

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Related Experiment Video

Updated: Nov 9, 2025

Fabrication of Compressed Hosiery and Measurement of its Pressure Characteristic Exerted on the Lower Limbs
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Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial

Ankur Thapar1,2,3, Rebecca Lawton4, Laura Burgess4

  • 1Academic Section of Vascular Surgery, Imperial College London, London, UK a.thapar09@imperial.ac.uk.

BMJ Open
|April 13, 2021
PubMed
Summary

Graduated compression stockings may help prevent post-thrombotic syndrome (PTS) after deep vein thrombosis (DVT). This trial investigates their effectiveness in patients with above-knee DVT.

Keywords:
anticoagulationthromboembolismvascular medicine

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Area of Science:

  • Vascular Medicine
  • Clinical Trials
  • Public Health

Background:

  • Post-thrombotic syndrome (PTS) affects up to 50% of patients following deep vein thrombosis (DVT).
  • Preventing PTS is crucial for improving patient outcomes and quality of life after DVT.

Purpose of the Study:

  • To evaluate the efficacy of graduated compression stockings in preventing PTS in patients with above-knee DVT.
  • To assess the impact of compression therapy on the incidence and severity of PTS.

Main Methods:

  • A pragmatic, UK multicentre randomized trial involving adults with a first-time above-knee DVT.
  • The intervention group received anticoagulation plus graduated compression stockings (23-32 mmHg) for a median of 18 months.
  • The primary endpoint was PTS, assessed using the Villalta score, with analysis via time-to-event and cumulative incidence.

Main Results:

  • Data on the primary endpoint (PTS incidence and severity) are currently being collected and analyzed.
  • A process evaluation is examining adherence to compression stockings and the effectiveness of behavioral interventions.

Conclusions:

  • The study aims to provide evidence-based recommendations on the use of compression stockings for PTS prevention after DVT.
  • Findings will inform clinical practice guidelines and patient management strategies for DVT survivors.