Related Experiment Video
Updated: Nov 9, 2025
08:39
Fabrication of Compressed Hosiery and Measurement of its Pressure Characteristic Exerted on the Lower Limbs
Published on: May 27, 2020
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Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial
Ankur Thapar1,2,3, Rebecca Lawton4, Laura Burgess4
1Academic Section of Vascular Surgery, Imperial College London, London, UK a.thapar09@imperial.ac.uk.
BMJ Open
|April 13, 2021
Summary
Graduated compression stockings may help prevent post-thrombotic syndrome (PTS) after deep vein thrombosis (DVT). This trial investigates their effectiveness in patients with above-knee DVT.
Area of Science:
- Vascular Medicine
- Clinical Trials
- Public Health
Background:
- Post-thrombotic syndrome (PTS) affects up to 50% of patients following deep vein thrombosis (DVT).
- Preventing PTS is crucial for improving patient outcomes and quality of life after DVT.
Purpose of the Study:
- To evaluate the efficacy of graduated compression stockings in preventing PTS in patients with above-knee DVT.
- To assess the impact of compression therapy on the incidence and severity of PTS.
Main Methods:
- A pragmatic, UK multicentre randomized trial involving adults with a first-time above-knee DVT.
- The intervention group received anticoagulation plus graduated compression stockings (23-32 mmHg) for a median of 18 months.
- The primary endpoint was PTS, assessed using the Villalta score, with analysis via time-to-event and cumulative incidence.
Main Results:
- Data on the primary endpoint (PTS incidence and severity) are currently being collected and analyzed.
- A process evaluation is examining adherence to compression stockings and the effectiveness of behavioral interventions.
Conclusions:
- The study aims to provide evidence-based recommendations on the use of compression stockings for PTS prevention after DVT.
- Findings will inform clinical practice guidelines and patient management strategies for DVT survivors.
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