Related Experiment Video
Updated: Nov 9, 2025

08:03
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
2.6K
Go Get Data (GGD) is a framework that facilitates reproducible access to genomic data
Michael J Cormier1,2, Jonathan R Belyeu1,2, Brent S Pedersen1,2
1Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.
Nature Communications
|April 13, 2021
Summary
Genomic data integration is challenging due to diverse formats and platforms. Go Get Data (GGD) offers a fast, reproducible method to install standardized data recipes, simplifying genomic data management for researchers.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- The exponential growth of genomic data presents significant opportunities for biological research.
- Integrating diverse genomic datasets from various platforms and formats is a major challenge.
- Inconsistent data formats and multiple genome builds complicate data collection, annotation, and transformation.
Purpose of the Study:
- To develop a streamlined and reproducible method for accessing and integrating diverse genomic datasets.
- To address the complexities associated with managing and combining data from multiple sources.
- To save researchers time and enhance the reproducibility of genomic studies.
Main Methods:
- Development of Go Get Data (GGD), a software tool for installing standardized data recipes.
- GGD provides a fast and reproducible approach to data acquisition and preparation.
- The system is designed to be extensible to various data types beyond genomics.
Main Results:
- GGD simplifies the process of collecting, annotating, transforming, and integrating genomic data.
- The tool ensures a fast and reproducible workflow for data management.
- Successful implementation of standardized data recipes through GGD.
Conclusions:
- Go Get Data (GGD) effectively streamlines genomic data integration.
- The tool enhances research reproducibility and saves valuable researcher time.
- GGD is a valuable resource for the bioinformatics community, available on GitHub.
Related Concept Videos
Genome-wide Association Studies-GWAS
14.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.9K
Evolutionary Relationships through Genome Comparisons
6.5K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.5K
Genomics
38.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
38.5K
Genome Annotation and Assembly
19.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
19.8K
Genetic Screens
5.3K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.3K

