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Hemoglobin Brest [beta 127 (H5)Gln----Lys] a new unstable human hemoglobin variant located at the alpha 1 beta 1
V Baudin-Chich1, H Wajcman, G Gombaud-Saintonge
1INSERM U299, Le Kremlin-Bicêtre, France.
Hemoglobin
|January 1, 1988
Abstract:
Hb Brest [beta 127 (H5)Gln----Lys] is a new unstable variant located at the alpha 1 beta 1 interface at the same position as Hb Complutense [beta 127(H5)Gln----Glu]. In each of these, the substitution produces a distinct alteration in charge, yet both variants move with Hb A in conventional electrophoresis. This peculiar electrophoretical behavior may be due to the molecular position of the modified residue, which is deeply buried inside the tetramer.