Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local stem cell depletion model for radiation myelitis.

R J Yaes1, A Kalend

  • 1Department of Radiation Medicine, University of Kentucky Medical Center, Lexington 40536.

International Journal of Radiation Oncology, Biology, Physics
|June 1, 1988
PubMed
Summary

This study introduces a critical volume model for normal tissue damage, suggesting a single stem cell can repair a limited organ volume. Model predictions align with rat radiation myelitis data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Late normal tissue injury from permanent interstitial implants.

International journal of radiation oncology, biology, physics·2001
Same author

Defining a uniform biologically effective dose for organs with parallel architecture.

International journal of radiation oncology, biology, physics·2000
Same author

The slope of the sigmoid dose response curve for tumor control.

International journal of radiation oncology, biology, physics·2000
Same author

Collective bargaining for house staff.

The New England journal of medicine·2000
Same author

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.

Gene therapy·2000
Same author

Point dose variations with time during traditional brachytherapy for cervical carcinoma.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2000

Area of Science:

  • Radiation oncology
  • Stem cell biology
  • Biophysics

Background:

  • Normal tissue damage limits radiation therapy efficacy.
  • Adult mammalian stem cells are assumed to have limited mobility.
  • A critical volume (Vc) concept is proposed for stem cell repopulation capacity.

Purpose of the Study:

  • To develop a quantitative model for normal tissue radiation damage.
  • To predict the probability of radiation-induced myelitis.
  • To explore the applicability of the critical volume concept to other organs.

Main Methods:

  • A 1-dimensional model of the spinal cord was developed.
  • The critical volume was defined as a 'slice' of thickness 't'.
  • Myelitis probability was derived as a function of dose, dose per fraction, irradiated length, slice thickness, stem cell number, and survival curve parameters (alpha and beta).

Related Experiment Videos

Main Results:

  • A triple negative exponential dose-response function for complication probability was derived.
  • The model predicts steep dose-response curves with short tails.
  • Model predictions demonstrated compatibility with experimental data for radiation myelitis in rats.

Conclusions:

  • The critical volume model provides a framework for understanding normal tissue damage.
  • The model's predictions are consistent with experimental findings in rats.
  • The critical volume concept may be applicable to other organs like skin and kidney.