[Dyslipidemias: new therapeutic targets and relevance of combination therapies]

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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Marcello Arca1, Stefania Angela Di Fusco2

  • 1Dipartimento di Medicina Traslazionale e di Precisione, Sapienza Università di Roma, Roma.

Giornale Italiano Di Cardiologia (2006)
|April 13, 2021
PubMed

Insights

New guidelines lower low-density lipoprotein cholesterol (LDL-C) targets for high-risk patients. Real-world data show a gap in achieving these LDL-C goals, highlighting the need for combination therapies and new drugs like bempedoic acid.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Growing evidence links lower low-density lipoprotein cholesterol (LDL-C) levels to improved patient prognosis.
  • Updated 2019 European Society of Cardiology guidelines have intensified LDL-C targets for individuals at higher cardiovascular risk.

Purpose of the Study:

  • To address the discrepancy between guideline-recommended LDL-C targets and real-world achievement.
  • To explore effective therapeutic strategies for managing hypercholesterolemia in high-risk populations.

Main Methods:

  • Analysis of national and international observational clinical studies.
  • Review of current treatment strategies and emerging pharmacological options for lipid management.

Main Results:

  • Significant gap identified between recommended and achieved LDL-C levels in real-world settings, particularly for high-risk patients.
  • Combination treatment strategies are effective and safe for reaching target LDL-C levels.

Conclusions:

  • Combination therapy with multiple lipid-lowering drugs is crucial for achieving guideline-recommended LDL-C targets.
  • New agents, including bempedoic acid, expand therapeutic options for hypercholesterolemia management.

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