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Lifetime occupational exposure proportion estimation methods: a sensitivity analysis in the general population.

Marie-Tülin Houot1, Julie Homère2, Hélène Goulard2

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International Archives of Occupational and Environmental Health
|April 13, 2021
PubMed
Summary

Estimating lifetime occupational exposure proportion (LOEP) varies significantly by method. Job-period methods provide a recommended range for health monitoring, offering more comprehensive estimates than simpler career-maximum approaches.

Keywords:
Job-exposure matrix (JEM)Lifetime occupational exposure proportionPopulation-attributable fraction (PAF)PrevalenceStatistical method

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Area of Science:

  • Occupational Epidemiology
  • Exposure Assessment
  • Public Health

Background:

  • Accurate estimation of lifetime occupational exposure proportion (LOEP) is crucial for assessing population-attributable fraction (PAF) of diseases.
  • Existing methods for LOEP estimation vary, potentially impacting the reliability of health risk assessments.

Purpose of the Study:

  • To conduct a sensitivity analysis of commonly used LOEP estimation methods.
  • To evaluate the impact of different LOEP estimation techniques on both LOEP and PAF values.

Main Methods:

  • Utilized a French population-based sample (N=10,010) with complete job histories.
  • Linked data with four job-exposure matrices (flour, cement, silica, benzene).
  • Estimated LOEP using four methods: maximum career exposure probability (Proba_max), two job-period methods (job-period_M1, job-period_M2), and one job-year method.

Main Results:

  • The Proba_max method consistently yielded lower LOEP estimates compared to job-period or job-year methods across all agents.
  • Percentage variations in LOEP estimates ranged from 0% to 55.8% depending on the occupational agent.
  • Estimated cancer cases varied significantly, with a twofold factor for silica/lung cancer and a fourfold factor for benzene/acute myeloid lymphoma.

Conclusions:

  • Different LOEP estimation methods significantly influence PAF calculations.
  • For robust health monitoring, reporting a range of LOEP estimates derived from job-period methods (job-period_M1 and job-period_M2) is recommended.