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Related Experiment Video

Updated: Nov 9, 2025

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LGR6 marks nephron progenitor cells.

Ravian L van Ineveld1,2, Thanasis Margaritis1, Berend A P Kooiman1

  • 1Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|April 13, 2021
PubMed
Summary
This summary is machine-generated.

Researchers identified LGR6 as a novel marker for nephron progenitor cells (NPCs) undergoing mesenchymal-to-epithelial transition (MET). These LGR6+ cells are crucial for forming all nephron segments and possess regenerative potential.

Keywords:
3D imagingLGR6fatelineage tracingmesenchymal to epithelial transitionnephron progenitor cells

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Area of Science:

  • Nephrology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Nephron progenitor cells (NPCs) are essential for forming mature kidney structures through a process called mesenchymal-to-epithelial transition (MET).
  • A specific marker for NPCs undergoing MET during nephrogenesis has been lacking.
  • Understanding NPC differentiation is key to kidney development and regeneration.

Purpose of the Study:

  • To identify a novel marker for nephron progenitor cells (NPCs) during mesenchymal-to-epithelial transition (MET).
  • To investigate the role and developmental trajectory of LGR6+ cells in nephrogenesis.
  • To determine the potential of LGR6+ cells in kidney regeneration.

Main Methods:

  • Utilized lineage tracing in embryonic explants.
  • Employed confocal imaging and single-cell RNA sequencing.
  • Conducted long-term in vivo lineage tracing in postnatal models.

Main Results:

  • Identified LGR6 as a marker for NPCs, present from early cap mesenchyme through S-shaped bodies, tracking MET.
  • Demonstrated diverse cell fates of LGR6+ cells during embryonic kidney development.
  • Confirmed that postnatal LGR6+ cells can generate multiple nephron lineages.

Conclusions:

  • LGR6+ cells are identified as a critical early-committed NPC population.
  • These cells contribute to all nephrogenic segments via MET.
  • LGR6+ cells exhibit potential for kidney regeneration.