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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Nov 9, 2025

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
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Early stem cell aging in the mature brain.

Albina Ibrayeva1, Maxwell Bay2, Elbert Pu3

  • 1Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Davis School - Buck Institute Graduate Program in the Biology of Aging, University of Southern California, Los Angeles, CA 90033, USA.

Cell Stem Cell
|April 13, 2021
PubMed
Summary

Neural stem cells (NSCs) age and deplete asynchronously. Targeting tyrosine-protein kinase Abl1 with imatinib rejuvenates middle-aged NSCs, offering a potential strategy for age-related brain disorders.

Keywords:
AblImatinibadult neurogenesisagingbioinformaticscell fateclonal analysishippocampusinterventionproliferationquiescencesingle cell RNA-seqstem cell

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Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol
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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Aging Research

Background:

  • Stem cell dysfunction is a key driver of age-related diseases.
  • Understanding early mechanisms of stem cell compromise is crucial for promoting healthy aging and tissue function.

Purpose of the Study:

  • To identify factors disrupting neural stem cell (NSC) behavior in the adult hippocampus.
  • To investigate the role of molecular aging in NSC quiescence and function.

Main Methods:

  • Clonal tracing to distinguish short-term (ST-NSCs) and long-term (LT-NSCs).
  • Single-cell transcriptome analysis of quiescent NSCs.
  • Pharmacological inhibition of tyrosine-protein kinase Abl1 using imatinib.

Main Results:

  • NSCs exhibit asynchronous depletion, with ST-NSCs rapidly generating neurons and LT-NSCs entering prolonged quiescence.
  • Molecular aging hallmarks were identified in quiescent NSCs.
  • Tyrosine-protein kinase Abl1 was identified as a significant factor in NSC aging.
  • Imatinib treatment activated middle-aged NSCs without compromising their long-term maintenance.

Conclusions:

  • Hippocampal NSCs are uniquely vulnerable and adaptable to cellular aging.
  • Targeting Abl1 presents a promising therapeutic avenue for age-related decline in neural stem cell function.