Related Experiment Video

Updated: Nov 9, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

825

LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack

Jaganathan Venkatesh1, Marie-Claire D Wasson1, Justin M Brown1

  • 1Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.

Cancer Letters
|April 13, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) regulate key breast cancer mechanisms like EMT, CSCs, and drug resistance. Understanding their complex interactions is crucial for developing targeted therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Therapeutic effectiveness in breast cancer is often limited by complex pathogenic mechanisms.
  • Epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), and drug resistance are key challenges in breast cancer treatment.
  • Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are critical regulators of gene expression involved in these processes.

Purpose of the Study:

  • To summarize current literature on lncRNA-miRNA interactions in breast cancer.
  • To review the role of these interactions in EMT, CSCs, and drug resistance.
  • To explore both established and novel mechanisms of lncRNA-miRNA regulation in breast cancer.

Main Methods:

  • Literature review and synthesis of existing research on non-coding RNA interactions.
  • Analysis of molecular mechanisms underlying lncRNA-miRNA crosstalk.
  • Identification of regulatory networks impacting breast cancer progression.

Main Results:

  • lncRNA-miRNA axes play significant roles in regulating EMT, CSCs, and drug resistance in breast cancer.
  • These interactions form intricate regulatory networks influencing post-transcriptional gene expression.
  • The functional outcome of lncRNA-miRNA axes can be either tumor suppressive or oncogenic.

Conclusions:

  • Defining specific lncRNA-miRNA interactions is essential for identifying therapeutic targets in breast cancer.
  • Further research into these complex regulatory networks can uncover novel therapeutic strategies.
  • Understanding lncRNA-miRNA crosstalk is vital for overcoming treatment resistance and improving breast cancer outcomes.
Keywords:
Cancer stem cellsEpithelial-mesenchymal transitionLong-non-coding RNAsSpongingmicroRNAs

More Related Videos

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

6.9K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.1K