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Amygdala hyperconnectivity in the paranoid state: A transdiagnostic study.

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  • 1School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.

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Paranoia is linked to increased right amygdala connectivity with the prefrontal cortex and frontal cortex. This finding suggests a transdiagnostic neural mechanism for paranoia across different diagnoses.

Keywords:
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Paranoia causes significant social impairments in various clinical diagnoses.
  • Amygdala dysfunction is a known neurobiological marker for paranoia in schizophrenia.

Purpose of the Study:

  • Investigate amygdala functional connectivity (FC) in individuals experiencing paranoia across different diagnoses.
  • Identify potential transdiagnostic neural mechanisms underlying paranoia.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used.
  • Forty-five patients with paranoid ideation were compared to non-paranoid patients.
  • Amygdala FC was analyzed and correlated with paranoia scores in patients and healthy controls.

Main Results:

  • Increased right amygdala functional connectivity (FC) with the prefrontal cortex (PFC), frontal cortex, and insula was observed in the paranoid group.
  • No significant differences in left amygdala FC were found between groups.
  • Right amygdala FC with PFC and frontal cortex positively correlated with paranoia severity.

Conclusions:

  • Paranoia is associated with right amygdala hyperconnectivity to the PFC, frontal cortex, and insula.
  • This hyperconnectivity represents a potential transdiagnostic neural mechanism for paranoia.
  • Identifying this mechanism may aid in developing targeted treatments to improve social functioning.