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Adolescent perceptions of pharmacogenetic testing.

Stephani L Stancil1,2,3, Courtney Berrios4, Susan Abdel-Rahman2,3

  • 1Division of Adolescent Medicine, Children's Mercy Kansas City, MO 64108, USA.

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Summary

Adolescents understand pharmacogenetics (PGx) testing, viewing it as beneficial and low-risk for their care and peers. This highlights the need to involve them in shared decision-making for PGx testing and results discussion.

Keywords:
adolescentsimplementationpediatricspharmacogeneticspharmacogenomics

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Area of Science:

  • Pediatric pharmacogenetics research
  • Adolescent health outcomes
  • Genetics and personalized medicine

Background:

  • Pharmacogenetics (PGx) expansion has not included pediatric patient perspectives.
  • Understanding adolescent views on PGx testing is crucial for ethical implementation.
  • Limited data exists on how young patients perceive PGx utility and risks.

Purpose of the Study:

  • To explore adolescents' understanding of pharmacogenetics (PGx) testing.
  • To assess adolescent perceptions of PGx testing's impact on their health.
  • To evaluate adolescent views on the risks and benefits of PGx for themselves and peers.

Main Methods:

  • Qualitative interviews with adolescents who underwent PGx testing.
  • Review of electronic health records for context on PGx testing.
  • The study focused on adolescent participants' subjective experiences and understanding.

Main Results:

  • Adolescents accurately recalled reasons for PGx testing.
  • Most adolescents perceived PGx results as impactful for current and future care.
  • No participants foresaw risks to future employment or insurance from PGx testing.

Conclusions:

  • Adolescents demonstrate comprehension of PGx testing rationale and utility.
  • Adolescents perceive PGx testing as low-risk and beneficial for peers.
  • Findings support involving adolescents in shared decision-making and results discussions for PGx.