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Features of Antithrombotic Therapy in Patients with Multifocal Arterial Disease

V G Grachev1, S S Vedenskaya1, O G Smolenskaya1

  • 1Urals State Medical University of Ministry Healthcare of Russian Federation, Yekaterinburg.

Kardiologiia
|April 14, 2021
PubMed

Insights

Patients with multifocal arterial injury benefit from intensive antithrombotic therapy, including aspirin and rivaroxaban. This approach significantly reduces cardiovascular risks, improving patient outcomes and safety.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Pharmacology

Background:

  • Multifocal arterial injury is prevalent in atherosclerotic cardiovascular disease (ASCVD).
  • ASCVD with multifocal arterial injury elevates risks of cardiovascular events and mortality.
  • Current therapeutic strategies require optimization for this patient cohort.

Purpose of the Study:

  • To evaluate the efficacy and safety of intensive antithrombotic therapy in patients with multifocal arterial injury.
  • To assess the impact of combined acetylsalicylic acid and rivaroxaban on cardiovascular risk reduction.
  • To determine the role of peripheral artery disease detection in risk stratification and treatment decisions.

Main Methods:

  • Retrospective analysis of patients with atherosclerotic cardiovascular diseases and multifocal arterial injury.
  • Comparison of outcomes between standard and intensive antithrombotic regimens (acetylsalicylic acid + vascular dose rivaroxaban).
  • Assessment of cardiovascular complication rates, including ischemic events and mortality.

Main Results:

  • Intensive antithrombotic therapy demonstrated a favorable benefit-risk profile.
  • A significant decrease in the risk of cardiovascular complications was observed with combined therapy.
  • Early detection of peripheral artery disease aided in identifying patients for intensified treatment.

Conclusions:

  • Intensive antithrombotic therapy, specifically acetylsalicylic acid and rivaroxaban, offers improved efficacy and safety in multifocal arterial injury.
  • Peripheral artery disease detection is crucial for optimizing risk stratification and guiding antithrombotic treatment choices.
  • This approach enhances management strategies for patients with complex atherosclerotic disease.

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