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Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types
Sipeng Shen1,2,3, Ruyang Zhang3,4,5, Yue Jiang2,3
1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
Molecular Cancer
|April 14, 2021
Summary
N6-Methyladenosine (m6A) RNA modification patterns and interactive genes impact multiple cancer outcomes. Identifying m6A subtypes and signatures can reveal new therapeutic targets and inform treatment strategies across diverse cancers.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- N6-Methyladenosine (m6A) is a crucial RNA modification involved in cancer development.
- Previous studies on m6A's clinical impact are limited to single cancer types, hindering a comprehensive understanding.
Discussion:
- This study analyzed m6A modification patterns, regulators, and interactive RNAs in 9,804 pan-cancer samples to identify distinct m6A subtypes.
- Three m6A subtypes (immunological, intermediate, tumor proliferative) were identified, correlating with tumor microenvironment infiltration and overall survival in 24 of 27 cancer types.
- An unsupervised approach constructed an m6A signature associated with survival, tumor mutation burden, and key cancer pathways.
Key Insights:
- The study identified 114 novel potential m6A targets, with BCL9L being a commonly shared oncogene across cancer types, interacting with m6A within the Wnt signaling pathway.
- The prognostic value of one m6A target was validated in 3,444 samples across six external datasets.
- m6A regulators and their interactive genes demonstrably influence cancer patient outcomes.
Outlook:
- Individualized m6A signatures and subtype evaluation can guide the development of novel adjuvant therapies for various cancers.
- Further research into m6A's role in the tumor microenvironment and its interaction with signaling pathways like Wnt may reveal new therapeutic strategies.
