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Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action

Amira Mohammed Ali1,2, Hiroshi Kunugi3,4

  • 1Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. mercy.ofheaven2000@gmail.com.

Diagnostic Pathology
|April 14, 2021
PubMed

Insights

Hypoproteinemia, or low protein levels, is common in hospitalized COVID-19 patients. This condition contributes to disease severity and adverse outcomes, particularly in older adults.

Area of Science:

  • Biochemistry
  • Immunology
  • Critical Care Medicine

Background:

  • Proteins are essential for tissue structure and cellular signaling.
  • Coronavirus disease 2019 (COVID-19) is linked to high mortality, especially in the elderly, often due to lung damage and organ failure.
  • COVID-19 induces a hypercatabolic state, leading to significant protein loss.

Discussion:

  • This review examines hypoproteinemia in symptomatic and hospitalized COVID-19 patients.
  • It focuses on the underlying pathophysiology, diagnostic screening methods, and the impact on disease progression.
  • The role of hypoproteinemia in COVID-19 severity and adverse effects is critically analyzed.

Key Insights:

  • Hypoproteinemia is a significant complication in COVID-19 patients.
  • Low protein levels are associated with increased disease severity and poorer outcomes.
  • Understanding hypoproteinemia is crucial for managing COVID-19 patients.

Outlook:

  • Further research into the mechanisms linking hypoproteinemia and COVID-19 severity is warranted.
  • Development of targeted interventions to address protein loss in COVID-19 patients may improve outcomes.
  • Clinical guidelines should consider screening for and managing hypoproteinemia in hospitalized COVID-19 cases.

Keywords:
*albumin*Blood urea nitrogenCOVID-19Coronavirus disease 2019Disease severityHypoproteinemiaIntensive care unitMalnutritionMortalityMultiple organ failure

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