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Updated: Nov 9, 2025
Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
Published on: March 1, 2024
ROSE in Rosai-Dorfman-Destombes (RDD) disease: a cytological diagnosis
Santosh Tummidi1, Hemant Kumar Singh2, Prudhvinath A Reddy3
1Department of Pathology, AIIMS, Mangalagiri, Guntur, A.P., India, 522503. born_vss@yahoo.co.in.
Background:
Rosai-Dorfman-Destombes (RDD) is also known as sinus histiocytosis with massive lymphadenopathy (SHML). It is a benign proliferative disorder of histiocytes, affecting lymph nodes, rarely with extra-nodal involvement. Rapid on-site evaluation (ROSE) with fine-needle aspiration cytology (FNAC) can be utilized as a minimally invasive investigation to avoid unnecessary surgery of this self-limiting disease.
Case Presentation:
A 65-year-old female presented with complaints of bilateral cervical lymphadenopathy since 1 year. Rapid on-site stain with FNAC from bilateral cervical lymph nodes revealed features of Rosai-Dorfman-Destombes (RDD) disease.
Conclusion:
FNAC with rapid on-site evaluation can provide a simple and cost-effective method for looking at the unique cytological features of the disease and act as a first-line investigation.
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