Circulating IL-37 levels are elevated in patients with hypertension.
Jing Ye1,2, Yuan Wang3, Zhen Wang2
1Department of Cardiology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China.
Experimental and Therapeutic Medicine
|April 14, 2021
Summary
Interleukin-37 (IL-37) is elevated in hypertension patients, particularly in macrophages. Higher IL-37 levels correlate with blood pressure and carotid atherosclerotic plaque, suggesting a role in hypertension-related vascular disease.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Hypertension Research
Background:
- Interleukin-37 (IL-37) is implicated in vascular diseases like atherosclerosis.
- Hypertension is a major risk factor for cardiovascular complications.
Purpose of the Study:
- To investigate IL-37 expression in hypertension patients.
- To determine the association between IL-37 levels and hypertension, and related vascular conditions.
Main Methods:
- Measured IL-37 mRNA in isolated immune cells (macrophages, lymphocytes, dendritic cells) from controls and hypertension patients.
- Assessed circulating IL-37 levels in a larger cohort of controls and hypertension patients.
- Correlated IL-37 levels with blood pressure, clinical factors (smoking, diabetes), and carotid atherosclerotic plaque (CAP).
Main Results:
- Elevated IL-37 mRNA in macrophages, but not lymphocytes or dendritic cells, from hypertension patients.
- Increased circulating IL-37 levels in hypertension patients, positively correlated with systolic and diastolic blood pressure.
- Higher IL-37 levels observed in hypertensive patients with smoking, diabetes, or CAP; positively correlated with creatinine, CRP, and homocysteine.
- IL-37 levels were independently associated with the presence of CAP.
Conclusions:
- IL-37 is upregulated in hypertension patients, especially in macrophages.
- Circulating IL-37 levels are elevated and linked to blood pressure and vascular complications like CAP in hypertension.
- IL-37 may play a significant role in the pathogenesis of hypertension and its associated vascular damage.
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