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Apathy Antedating and Evolving With Dementia: A Case Report and Insights Into Apathy as a Network Dysfunction
1Neurology, Flowers Medical Group, Dothan, USA.
Cureus
|April 14, 2021
Summary
Apathy, a motivational disorder, is increasingly understood as a network dysfunction. This case study explores apathy
Area of Science:
- Neuroscience
- Neurology
Background:
- Apathy is a motivational disorder characterized by a lack of drive.
- Historically linked to the ergotropic sympathetic pathway and posterior hypothalamus.
- Recent research implicates the dopaminergic mesolimbic system and salience network.
Observation:
- Presents a case of apathy preceding and evolving with Alzheimer's disease.
- Highlights the role of the Papez circuit in apathy pathogenesis.
Findings:
- Apathy is best understood as a complex network disorder.
- Network dysfunction spans multiple brain regions including the hypothalamus, thalamus, cingulate cortex, hippocampus, and mesolimbic system.
Implications:
- Understanding apathy as a network disorder is crucial for neurodegenerative diseases like Alzheimer's.
- Explores potential pharmacological therapies targeting these neural networks.
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