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Evaluation of the use of chlorpromazine for agitation in pediatric patients

Rajwoana Ahmed1, Megan Maroney2, Germin Fahim3

  • 1Pharmacist, Pharmacy Department, Monmouth Medical Center, Long Branch, New Jersey, rajwoana@gmail.com.

The Mental Health Clinician
|April 14, 2021
PubMed

Insights

Chlorpromazine use in pediatric agitation showed significant issues, including drug interactions, inefficacy, and side effects. This highlights a need for improved treatment strategies and medication management for better patient outcomes.

Area of Science:

  • Pediatric pharmacology
  • Clinical pharmacy
  • Behavioral health

Background:

  • Chlorpromazine, a first-generation antipsychotic, is a standard treatment for pediatric agitation.
  • Alternative therapies may offer better outcomes and fewer adverse effects.
  • This study evaluated chlorpromazine's appropriateness in pediatric agitation management.

Purpose of the Study:

  • To assess the efficacy of chlorpromazine for pediatric agitation.
  • To evaluate appropriate dosing and identify drug interactions.
  • To determine the tolerability and side effects of chlorpromazine in children.

Main Methods:

  • Retrospective chart review of pediatric patients receiving chlorpromazine from January 2019 to June 2019.
  • Data collected included drug interactions, dosing, efficacy, and side effects.
  • Descriptive statistics were used to analyze the incidence of adverse events and treatment effectiveness.

Main Results:

  • 130 administrations of chlorpromazine in 70 patients were analyzed.
  • 38% of administrations involved a drug-drug interaction (DDI).
  • 14% were ineffective, 8% were inappropriately dosed, and 35% caused side effects.

Conclusions:

  • The study identified significant issues with chlorpromazine use in pediatric agitation.
  • Instances of DDIs, inefficacy, dosing errors, and side effects indicate a need for improved clinical practice.
  • Optimizing treatment requires careful consideration of chlorpromazine's risks and benefits.
Abstract

Keywords:
agitationchlorpromazineolanzapinepediatricssedation

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