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Novel double beta-lactam therapy for Granulicatella adiacens infective endocarditis

S Khan1, C Urban1,2, V Singh3

  • 1The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA.

Idcases
|April 14, 2021
PubMed

Insights

This study presents the first successful treatment of Granulicatella adiacens endocarditis using ampicillin and ceftriaxone. The combination therapy demonstrated synergistic activity against this rare bacterial infection.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Granulicatella adiacens, a nutritionally variant streptococci (NVS), is a known cause of infective endocarditis.
  • Previous studies have shown efficacy of dual beta-lactam therapy for endocarditis caused by other bacteria.

Observation:

  • A case of infective endocarditis caused by Granulicatella adiacens is described.
  • The patient was treated with a combination of intravenous ampicillin and ceftriaxone.

Findings:

  • This is the first reported case of Granulicatella adiacens endocarditis successfully treated with ampicillin and ceftriaxone.
  • The study documents the synergistic activity of this antibiotic combination against Granulicatella adiacens.

Implications:

  • Ampicillin and ceftriaxone combination therapy is a viable treatment option for Granulicatella adiacens endocarditis.
  • This finding expands treatment options for rare infectious endocarditis cases.
  • Further research into synergistic antibiotic combinations for NVS infections is warranted.
Keywords:
Double beta-lactam therapyGranulicatella adiacensInfective endocarditisSynergy

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